منابع مشابه
Lysosome-endosome fusion and lysosome biogenesis.
Recent data both from cell-free experiments and from cultured cells have shown that lysosomes can fuse directly with late endosomes to form a hybrid organelle. This has a led to a hypothesis that dense core lysosomes are in essence storage granules for acid hydrolases and that, when the former fuse with late endosomes, a hybrid organelle for digestion of endocytosed macromolecules is created. L...
متن کاملLysosome Transport as a Function of Lysosome Diameter
Lysosomes are membrane-bound organelles responsible for the transport and degradation of intracellular and extracellular cargo. The intracellular motion of lysosomes is both diffusive and active, mediated by motor proteins moving lysosomes along microtubules. We sought to determine how lysosome diameter influences lysosome transport. We used osmotic swelling to double the diameter of lysosomes,...
متن کاملLysosome-related organelles.
Lysosomes are membrane-bound cytoplasmic organelles involved in intracellular protein degradation. They contain an assortment of soluble acid-dependent hydrolases and a set of highly glycosylated integral membrane proteins. Most of the properties of lysosomes are shared with a group of cell type-specific compartments referred to as 'lysosome-related organelles', which include melanosomes, lytic...
متن کاملPIPing on lysosome tubes.
The role of lysosomes in important cellular responses, including phagocytosis, cell surface repair, and autophagy underlies a number of human diseases. Furthermore, the role of the lysosomal surface in TORC1 signalling has revealed unexpected properties of these organelles. In this issue, Sridhar et al (2013) uncover an important role for PI(4)P for lysosome function under normal nutrient condi...
متن کاملThe awesome lysosome.
In the early 50s, Christian De Duve identified a new cellular structure, the lysosome, defined as the cell’s “suicide bag” (de Duve, 2005). Sixty years later, it is clear that the lysosome greatly exceeded the expectations of its discoverer. Over 50 different types of lysosomal storage diseases have been identified, each due to the deficiency or malfunction of a specific lysosomal protein. In a...
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ژورنال
عنوان ژورنال: Journal of Inborn Errors of Metabolism and Screening
سال: 2016
ISSN: 2326-4098,2326-4594
DOI: 10.1177/2326409816679431